ABSTRACT
To investigate the ethanolic root bark extract of Icacina senegalensis for antinociceptive, anti-inflammatory and antipyretic activities in rats and mice. Acetic acid-induced abdominal constriction and tail immersion tests were used to evaluate the antinociceptive activity of the extract. Egg albumin and carrageenan-induced paw oedema were used to study the anti-inflammatory activity, whereas the anti-pyretic studies were evaluated on yeast and amphetamine-induced pyrexia. The root bark extract (50, 100 and 200 mg/kg) significantly (P<0.05) showed inhibitory activity for all the models in the antinociceptive, anti-inflammatory and antipyretic assayed. Result shows that ethanolic root bark extract of Icacina senegalensis possesses phytochemicals with therapeutic potential against painful, inflammatory and feverish conditions, and thus explain the use of Icacina senegalensis for similar ailments in traditional medicine.
ABSTRACT
The objective of this study was to investigate the antibacterial and antioxidant activities of the methanol leaf extract of Maerua crassifolia, an important medicinal plant used in Nigeria. The antibacterial properties of the methanol extract were studied against clinically important bacteria viz; Staphylococcus aureus, Shigella spp., Salmonella typhi, Bacillus subtilis and Escherichia coli by disc diffusion method. The free radical scavenging potential of the extract was assessed by measuring its capability for scavenging 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical. The methanol leaf extract of Maerua crassifolia at the concentration of 12.5-150 μg/ml, showed significant activity against all the tested organisms. The observed antioxidant activity of the leaf extract suggests that the extract is a potential source of natural antioxidant and could be useful in the treatment of diseases.
ABSTRACT
OBJECTIVE@#To evaluate in vivo antimalarial activity of methanol leaf extract of Icacina senegalensis.@*METHODS@#The extract was investigated for activity against early and established malaria infections using Swiss albino mice infected with Plasmodium berghei at dose levels of 25, 50 and 100 mg/kg. Chloroquine (10 mg/kg) was used as positive control.@*RESULTS@#A dose dependent chemo-suppression of the parasites was observed at different dose levels of the extract tested with a considerable mean survival time.@*CONCLUSIONS@#The results support further investigation on components of traditional medicines as potential new antimalarial agents.
ABSTRACT
Objective: To evaluate in vivo antimalarial activity of methanol leaf extract of Icacina senegalensis. Methods: The extract was investigated for activity against early and established malaria infections using Swiss albino mice infected with Plasmodium berghei at dose levels of 25, 50 and 100 mg/kg. Chloroquine (10 mg/kg) was used as positive control. Results: A dose dependent chemo-suppression of the parasites was observed at different dose levels of the extract tested with a considerable mean survival time. Conclusions: The results support further investigation on components of traditional medicines as potential new antimalarial agents.
ABSTRACT
OBJECTIVE@#To investigate the antimalarial activity of ethanol extract of Aspilia africana (A. africana) leaf.@*METHODS@#The ethanol extract of A. africana leaf (100-400 mg/kg) was screened for blood schizonticidal effect against chloroquine-sensitive Plasmodium berghei (P. berghei) in mice both in early and established models of antimalarial studies.@*RESULTS@#The leaf extract exhibited significant (P<0.05) antiplasmodial activity in 4-day early infection and in established infection tests with a considerable mean survival time comparable to that of standard drug, chloroquine (10 mg/kg).@*CONCLUSIONS@#The findings show that ethanol extract of A. africana leaf possesses potent antiplasmodial activity which justify the use in ethnomedicine and can be developed in malaria therapy.